Vol. 2, Issue 2, Part B (2025)

Stress is a pervasive health concern, affecting physical, mental, and social well-being globally. Ayurveda offers holistic strategies for stress management, which is conceptualized as Manasika Vyadhi, a fundamental disturbance of the Manovaha Srotas influenced by the mental qualities of Rajas (agitation) and Tamas (inertia). Mechanistically, chronic stress is linked to the hyperactivity of the HPA axis and increased cortisol levels. Ayurvedic management aims to restore Sattva guna (clarity) and harmonize the Tridosha through comprehensive strategies, including Ahara (diet), Vihara (lifestyle), and Medhya Rasayana (cognitive-enhancing herbs). This review examines the therapeutic role of six key Medhya Rasayana: Ashwagandha (Withania somnifera), Brahmi (Bacopa monnieri), Shankhapushpi (Convolvulus pluricaulis), Mandukaparni (Centella asiatica), Yashtimadhu (Glycyrrhiza glabra), and Guduchi (Tinospora cordifolia). Modern research validates their traditional uses; for example, Ashwagandha modulates the HPA axis, demonstrating significant adaptogenic and anxiolytic effects. Brahmi enhances memory and cognition through neuroprotective and antioxidant properties. Shankhapushpi and Yashtimadhu provide synergistic support against anxiety and oxidative stress, while Guduchi supports neuroimmune homeostasis. By integrating these classical Ayurvedic principles with contemporary pharmacological evidence, provides a robust, evidence-based framework for enhancing mental resilience, promoting neuroimmune homeostasis, and supporting the body's holistic adaptation to stress. This review highlights the need for standardization and clinical validation of Medhya Rasayana in stress-related disorders.